Serum for near atopical skin

Vitamin C 10 %
Ginkgo Biloba
Green tea extract
Vitis vinifera extract

Vitamin C and atopy

Status of Vitamin C in patients with atopic dermatitis
Patients with atopic dermatitis would have lower levels of Vitamin C compared to healthy subjects. A first study performed by Leveque and al showed that Ascorbic Acid levels in the dermis of patients with atopic dermatitis were inferior to those of healthy volunteers. This phenomenon could be explained by the consumption of Vitamin C who scavenges the reactive oxygen species involved during the inflammatory process. The authors concluded that the evaluation of the Ascorbic Acid levels could be useful to characterize inflammatory skin diseases. This decline could also be due to Vitamin C who serves to the regeneration of Vitamin E or by its antagonism with histamine.

In another trial whose aim was to examine the food intake of patients with atopic dermatitis, Barth and al attributed this decline to the fact that patients with atopic dermatitis would consume less fruits than asymptomatic persons. They observed that between 16 and 58 % of the symptomatic patients had a significantly lower consumption of fruits compared to controls thus leading to an inferior consumption of Vitamin C.

Effects of a supplementation of Vitamin C
In a recent study, Hoppu and al showed that Vitamin C in breast milk could reduce the risks of atopy in the infant. The patients of this study were mothers with atopy and their infant aged of one month. Food intake of the mothers and their milk were analysed. The investigators concluded that Vitamin C concentration in the milk was dependent of the quantity consumed by the mother. On the other hand, the risk of atopy was weaker in infants whose mother had a higher concentration of Vitamin C in their milk. The group who was more likely to develop Vitamin C deficiencies was the same as the one with alimentary allergies.This study demonstrated that breastfeeding rich in Vitamin C could reduce the probability to develop atopy in high risk infants.

In a study made by Soutar and al, evidence was provided that a poor consumption in antioxidant and in consequence in Vitamin C increased the prevalence of atopy.

In their study on the increased oxidative stress in childhood atopic dermatitis, Omata and al came to the conclusion that the use of ant oxidative agents might be a potentially useful strategy for the treatment of atopic dermatitis.

Vitamin C in the restoration of the barrier effect
With the study performed by Ponec and al on different reconstructed epidermis, the authors came to the conclusion that the composition and the ceramide profile in the cell cultures normalized in the presence of Vitamin C who also improved the epidermal morphology and the stratum corneum ultrastructure. In addition, Vitamin C supplementation leads to a marked improvement of the stratum corneum lipid organization. The primary role of Vitamin C could most probably be ascribed to Vitamin-C induced facilitation of hydroxylation of sphingoid bases and of fatty acids and not to its anti-oxidative activity in preventing the formation of free oxygen radicals or lipid peroxides. The finding that only skin equivalents formed in Vitamin-C supplemented medium are capable of synthesizing sufficient amounts of all glucosylceramide classes indicates the crucial role of Vitamin-C in the regulation of the synthesis of competent barrier lipids.

Clinical trial

Efficacy and tolerance of CATOPIX-C clinically assessed

Prospective study performed by Pr P. Humbert at the University
of Besançon, September 2005:

• Double blind study Catopix-C versus excipient • Patients with atopic eczema from light to moderate • Two pulverisations twice a day • Measurement of SCORAD, localized SCORAD, transepidermal water loss, hydratation index, dryness index and ph • Evaluation of the well-being sensation and the tolerance

Composition

CATOPIX-C has the following active components:

• Double blind study Catopix-C versus excipient • Patients with atopic eczema from light to moderate • Two pulverisations twice a day • Measurement of SCORAD, localized SCORAD, transepidermal water loss, hydratation index, dryness index and ph • Evaluation of the well-being sensation and the tolerance

Mode of action

The efficacy of CATOPIX-C is based on two additive effects:

1.	It restores the barrier effect of the skin by supplementing the dermis in Vitamin C. The latter leads to a marked improvement of the SC lipid organization: composition and ceramide profile in reconstructed epidermis are normalized in the presence of Vitamin C.
2.	It prevents the oxidative stress and reduces the inflammatory events who are characteristic of the atopic skin.

The anti oxidizing power of the Vitamin C is reinforced with Gingko Biloba extract.

Instructions for use

Apply CATOPIX-C twice daily to sensitive areas. The product is easily absorbed into the skin. In order to avoid staining, wait a few minutes, leaving a feeling of comfort and well-being.


Warning

Do not allow the product to come into the contact with the eyes. In the event of accidental contact, rinse the eyes thoroughly with water.


Bibliography

• Leveque N, Robin S, Muret P, Mac-Mary S, Makki S, Humbert P. High iron and low ascorbic acid concentrations in the dermis of atopic dermatitis patients. Dermatology. 2003; 207(3): 261-4.

• Hoppu U, Kalliomaki M, Isolauri E. Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant. Eur J Clin Nutr. 2000 Sep; 54(9): 702-5.

• Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A, Jiang M, Hiraoka M, Nambu M, Deguchi Y, Mayumi M. Increased oxidative stress in childhood atopic patients. Life Sciences. 2001 Jun; 69(2): 223-228.

• Barth GA, Weigl L, Boeing H, Disch R, Borelli S. Food intake of patients with atopic dermatitis. Eur J Dermatol. 2001 Jun; 11(3): 199-202.

• Vega C. Higher Concentration of Vitamin C in Breast Milk Linked to Lower Rate of Infant Atopy. Eur J Clin Nutr. 2005 Aug; 59: 123-128.

• Ponec M, Weerheim A, Kempenaar J, Mulder A, Gooris GS, Bouwstra J, Mommaas AM. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol. 1997 Sep; 109(3): 348-55.

• Hoppu U, Rinne M, Salo-Vaananen P, Lampi A-M, Piironen V, Isolauri E. Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr. 2005 ; 59: 123-128.